Progress in research on the effects of different glucagon-like peptide-1 receptor agonists on bone metabolism

Author: Lingling LI ¹ ; Yangyang ZHANG ¹ ; Jia BAI ¹ ; Hong YANG ¹ ; Ying YANG ¹ ; Lingling LI ² ; Yangyang ZHANG ² ; Jia BAI ² ; Hong YANG ² ; Ying YANG ² ; Haihong LV ²
Author Information

1. The First Clinical Medical College of Lanzhou University
2. Department of Endocrinology, The First Hospital of Lanzhou University
Publication Type:Journal Article
Keywords: bone metabolism; diabetes; fracture risk; glucagon-like peptide-1 receptor agonists
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(11):1315-1320
CountryChina
Language:Chinese
Abstract: Osteoporosis is one of the common complications of type 2 diabetes mellitus (T2DM). Recent studies have shown that glucagon-like peptide-1 receptor agonists (GLP-1RAs) can promote bone formation and inhibit bone resorption, suggesting that this hypoglycemic drugs may benefit T2DM patients with osteoporosis and high fracture risk, but its underlying mechanism is not fully understood, and different GLP-1RAs exhibit different skeletal effects and molecular mechanisms. In this paper, the effects of several GLP-1RAs on bone metabolism are reviewed.