Role of vitamin D and ACE2 in COVID-19
10.12092/j.issn.1009-2501.2022.11.012
- Author:
Jiawei TANG
1
;
Xiangzhe MENG
1
;
Xuemin SUN
1
;
Yuexuan LI
1
;
Xue LIU
1
;
Hong WEI
1
Author Information
1. School of Basic Medicine Sciences, Jining Medical University
- Publication Type:Journal Article
- Keywords:
angiotensin-converting enzyme 2;
COVID-19;
SARS-CoV-2;
vitamin D
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(11):1292-1298
- CountryChina
- Language:Chinese
-
Abstract:
The spread of COVID-19 has greatly threatened human health and economic growth. Angiotensin-converting enzyme 2 (ACE2) is a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). By attaching to ACE2, SARS-COV-2 reduces its expression and induces lung injury. Vitamin D can inhibit the progression of COVID-19 by inhibiting the activity of ROCK pathway, up-regulating ACE2 expression and bio-availability, and slowing down the adverse reactions caused by Ang II accumulation. This study explored a novel mechanism, i.e., vitamin D protects against COVID-19-induced injury by upregulating ACE2 expression. It provides theoretical guidance for the role of Vitamin D in the prevention and treatment of COVID-19.
