Establishment of a limited sampling strategy to estimate micafungin exposure in critically ill patients
10.12092/j.issn.1009-2501.2022.11.008
- Author:
Jie HE
1
;
Lingjun ZHONG
1
;
Hua SHAO
1
;
Linlin HU
1
;
Dongxue LIU
2
;
Linlin HU
3
Author Information
1. Department of pharmacy, Zhongda Hospital, Southeast University
2. School of Basic Medicine and Clinical pharmacy, China pharmaceutical University
3. Office of Clinical Trial lnstitution, Zhongda Hospital, Southeast University
- Publication Type:Journal Article
- Keywords:
limited sampling strategy;
micafungin;
therapeutic drug monitoring;
ultra high performance liquid chromatography
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(11):1264-1271
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish an ultra high performance liquid chromatography (UPLC) method for the determination of micafungin in plasma of critically ill patients. And to establish a model for estimating the area under the concentration-time curve (AUC) of micafungin by limited sampling strategy. METHODS: Patients with severe infection were administrated with micafungin once a day, 1 h for each infusion. The blood samples were collected before administration and 1, 2, 4, 8, 12, 24 h after administration and were measured by UPLC. The pharmacokinetic parameters were calculated by Phoenix winnonlin 6.4, and the drug concentrations at 2-4 blood collection points were analyzed with SPSS 22.0 to establish limited sampling models. RESULTS: The calibration curve was linear over a concentration range of 1.0 to 50 μg/mL (r
