Model informed precision dosing of warfarin: China expert consensus report (2022 version)
- Author:
Jinhua ZHANG
;
Maobai LIU
;
Mingzhi CAI
;
Yingli ZHENG
;
Haiyan LAO
;
Qian XIANG
;
Liping DU
;
Zhu ZHU
;
Jing DONG
;
Xiaocong ZUO
;
Xingang LI
;
Dewei SHANG
;
Bing CHEN
;
Yanrong YE
;
Yuzhu WANG
;
Jianjun GAO
;
Jian ZHANG
;
Wansheng CHEN
;
Haitang XIE
;
Zheng JIAO
- Publication Type:Journal Article
- Keywords: clinical decision supporting system; consensus; modeling and simulation; pharmacokinetics and pharmacodynamics; precision dosing; warfarin
- From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(11):1201-1212
- CountryChina
- Language:Chinese
- Abstract: Model informed precision dosing for warfarin is to provide individualized dosing by integrating information related to patient characteristics, disease status and pharmacokinetics /pharmacodynamics of warfarin, through mathematical modeling and simulation techniques based on the quantitative pharmacology. Compared with empirical dosing, it can improve the safety, effectiveness, economy, and adherence of pharmacotherapy of warfarin. This consensus report describes the commonly used modeling and simulation techniques for warfarin, their application in developing and adjusting dosing regimens, medication adherence and economy. Moreover, this consensus also elaborates the detailed procedures for the implementation in the warfarin pharmacy service pathway to facilitate the development and application of model informed precision dosing for warfarin.