Research progresses in toxic effects and mechanism of anesthetics on the developing nervous system

Author: Yiting YAO ¹ ; Hanyu LIU ¹ ; Zifeng WU ¹ ; Di WANG ¹ ; Chun YANG ¹ ; Chaoli HUANG ¹
Author Information

1. Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University
Publication Type:Journal Article
Keywords: anesthetics; developing period; nervous sestem; progresses; toxicity
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2022;27(12):1354-1364
CountryChina
Language:Chinese
Abstract: Anesthesia is indispensable for surgere, but a growing number of studies have confirmed its togic effects on the developing nervous sestem, and has attract increasing attentions from the scientific communite. In this review, we briefle introduce the preclinical and clinical studies on the neurotogic effects of anesthetic drugs on the developing brain, and summare the mechanisms from the aspects of molecular mechanisms (Ca