Research progress of Nrf2 signaling pathway in complications related to obstructive sleep apnea
10.12092/j.issn.1009-2501.2023.11.011
- Author:
Haobin ZHU
1
;
Hongmei YUE
1
;
Xingdong WU
1
;
Miaomiao LIU
1
;
Yating LI
1
;
Jinhui XU
1
;
Hongmei YUE
2
Author Information
1. The First Clinical Medical College of Lanzhou University
2. Department of Respiratory and Critical Care Medicine, Lanzhou University First Hospital
- Publication Type:Journal Article
- Keywords:
nuclear factor e2 correlated factor 2;
obstructive sleep apnea;
oxidative stress
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(11):1283-1291
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian cell defense mechanisms are constantly evolving in response to increasing endogenous and exogenous oxidative stress factors. In recent years, as research has deepened, nuclear factor E2-related factor 2 (Nrf2) has been hailed as a "star" molecule in antioxidant damage defense. Billions of dollars have been spent internationally on developing targeted activators or inhibitors. Obstructive sleep apnea (OSA) is the most common form of sleep breathing disorder in clinical practice. Oxidative stress is one of its main pathological mechanisms and is closely related to target organ damage in the heart, brain, lungs, kidneys, and other systems. Recent research has revealed the mechanistic relationship of the Nrf2 pathway in OSA complications, and some natural Nrf2 activators have demonstrated emerging therapeutic effects in animal experiments. However, the activation mode and effect pathway of Nrf2 in different target organs of OSA have not been clarified. Therefore, this article reviews the research progress of the Nrf2 pathway in OSA and its complications, to deepen understanding of the mechanism of OSA complications and provide a potential treatment strategy.
