Research progress on the relationship between pediatric epilepsy and vitamin D
10.12092/j.issn.1009-2501.2023.11.013
- Author:
Chenhao LI
1
;
Wenhao YAN
1
;
Yuxia CHAI
1
;
Zeyun LI
1
;
Xihua YU
2
;
Yanyan LI
3
;
Kun LI
3
;
Zeyun LI
3
Author Information
1. The First Affiliated Hospital of Zhengzhou University
2. SINOPHARM Xingsha Pharmaceuticals (Xiamen) Co., Ltd.
3. Huanghe Science and Technology College
- Publication Type:Journal Article
- Keywords:
anti-seizure medicine;
correlation;
pediatric epilepsy;
research progress;
vitamin D
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(11):1299-1306
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is a long-term, chronic, recurrent, multi-factorial, multi-symptomatic nervous system disease, and was caused by abnormal discharge of brain neurons. Etiology can cause irreversible brain dysfunction and even death. There are about 6.5 million children with epilepsy in China, with incidence rate twice that of adult, presenting serious threaten to children's growth and development. Vitamin D has been well-known for crucial importance to development of nervous, skeletal, and immune system. Studies have found that pediatric epilepsy as well as other neurological diseases were closely related with vitamin D deficiency. First, a large number of studies have shown that vitamin D in children with epilepsy is affected by epilepsy itself; second, the use of anti-seizure medicines can alter metabolism of vitamin D by inducing cytochrome oxidases; third, the inducement was concerned to varieties, combination and duration of anti-seizure medicines; fourth, it was expected that supplement of vitamin D during antiepileptic treatment would guarantee an improvement of treating given that anti-seizure medicines may lead to deficiency of vitamin D. Large numbers of researches have reported on the correlation ship between pediatric epilepsy and vitamin D. However, there is still a lack of systematic review. This article aims to retrospect the research progress of relationship between pediatric epilepsy and vitamin D, and provide valuable feedbacks on further treatment of pediatric epilepsy.
