Interactions and clinical significance of gut microbiota and levothyroxine

Jiating Zhou; Zilan Xie; Zhi LI; Jiating Zhou; Zilan Xie; Zhi LI; Jiating Zhou; Zilan Xie; Zhi LI; Jiating Zhou; Zilan Xie; Zhi LI; Xuan Zhang

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Interactions and clinical significance of gut microbiota and levothyroxine

Author: Jiating ZHOU ¹ ; Zilan XIE ¹ ; Zhi LI ¹ ; Jiating ZHOU ² ; Zilan XIE ² ; Zhi LI ² ; Jiating ZHOU ³ ; Zilan XIE ³ ; Zhi LI ³ ; Jiating ZHOU ⁴ ; Zilan XIE ⁴ ; Zhi LI ⁴ ; Xuan ZHANG ⁵
Author Information

1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University
2. Institute of Clinical Pharmacology, Central South University and Hunan Key Laboratory of Pharmacogenetics
3. Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education
4. National Clinical Research Center for Geriatric Disorders
5. General Surgery Department of the Second People's Hospital of Hunan
Publication Type:Journal Article
Keywords: clinical medication; gut microbiota; levothyroxine; pharmacokinetics
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(11):1307-1314
CountryChina
Language:Chinese
Abstract: Levothyroxine is a class of thyroid hormone medication mainly used in the clinical treatment of thyroid hormone replacement therapy and thyrotropin suppression therapy. In recent years, studies have found a close correlation between the human gut microbiota and the occurrence and development of thyroid diseases, as well as changes in thyroid hormone levels. Therefore, understanding the impact of levothyroxine on the gut microbiota, as well as the effects of the gut microbiota on the metabolism and absorption of levothyroxine, is of great significance for the treatment of thyroid diseases and the rational use of clinical medication. This article explores the interaction between the gut microbiota and levothyroxine and summarizes the current clinical findings of the gut microbiota in levothyroxine therapy.