Regulation mechanism of post-translational modification of farnesoid X receptor
10.12092/j.issn.1009-2501.2023.11.012
- Author:
Zhaofeng LIU
1
;
Ling LI
1
;
Shufang NA
1
;
Qifa YE
1
;
Jiang YUE
2
;
Qifa YE
3
Author Information
1. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation
2. Department of Pharmacology, Basic Medical School, Wuhan University
3. The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology
- Publication Type:Journal Article
- Keywords:
acetylation;
FXR;
methylation;
O-glycosylation;
phosphorylation;
sumoylation
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(11):1292-1298
- CountryChina
- Language:Chinese
-
Abstract:
Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acid that is involved in regulating gene expression related to bile acid, fat, glucose, and amino acid metabolism. The activity of FXR is regulated by a variety of post-translational modifications. Common post-translational modifications of FXR include O-GlcNAcylation, phosphorylation, acetylation, sumoylation, methylation, etc. These post-translational modifications may affect FXR binding of DNA and ligand, heterodimerization, and subcellular localization, and may specifically regulate downstream gene transcription and expression. Different post-translational modifications can lead to changes in FXR stability and biological function, which are closely related to the occurrence of diseases. This paper aims to review the post-translational modification of FXR in the past five years and the mechanisms involved in disease regulation, to explore the effects of post-translational modification on the physiological function of FXR and to provide a theoretical basis for mechanism research targeting FXR.
