Therapeutic effect of lienal polypeptide injection on bone marrow suppression and immunodeficiency in KM mice following chemotherapy
10.12092/j.issn.1009-2501.2023.09.005
- Author:
Ruyue WANG
1
;
Hongyu LI
1
;
Fei XIE
2
;
Xin WANG
2
;
Hongyu LI
2
Author Information
1. Institute of Microbiology, School of Life Sciences, Lanzhou University
2. School of Pharmacy, Lanzhou University
- Publication Type:Journal Article
- Keywords:
chemotherapy;
lienal polypeptide injection;
T lymphocytes
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(9):1000-1007
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To assess the therapeutic effect of lienal polypeptide injection (LPI) on bone marrow suppression and poor immunity in Kunming (KM) mice after the intervention of chemotherapy drug carboplatin (CBP), as well as its potential mechanisms. METHODS: KM female mice were randomly divided into control group, model group, low-dose lienal polypeptide, and high-dose lienal polypeptide treatment groups. On day 1, mice in the treatment group and model group were subjected to intraperitoneal single injection of carboplatin (70 mg / kg), to induce chemotherapy-induced bone marrow suppression in mice, while the control group was intervened with normal saline. From Day 2 to Day 16, the treatment groups received daily intraperitoneal injections of lienal polypeptide (60 mg · kg
