Functions of CRABP2 in tumorigenesis and progression
10.12092/j.issn.1009-2501.2023.01.011
- Author:
Jiajia LIU
1
;
Yan GAO
2
;
Yehui ZHANG
3
;
Jing WU
3
Author Information
1. Pharmacy Department of Laoling People's Hospital
2. Pharmacy Department of Second Hospital of Shandong University
3. Pharmacy Department of the First Affiliated Hospital of Shandong First Medical University, Qianfoshan Hospital of Shandong Province
- Publication Type:Journal Article
- Keywords:
CRABP2;
drug resistance;
initiation;
metastasis;
molecular marker;
tumor
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(1):86-92
- CountryChina
- Language:Chinese
-
Abstract:
Retinoic acid (RA) is a metabolic intermediate of vitamin A, which plays an important role in embryonic development and cell growth and differentiation. Cellular retinoic acid-binding proteins 2 (CRABP2) are a group of low-molecular weight intracellular proteins whose primary physiological function is to transport RA to the nucleus. Generally, CRABP2 binds to the retinoic acid receptor (RAR), then regulates specific downstream signaling pathways to function. Abnormal expression of CRABP2 was closely related to several human malignant tumors, and could affect the tumor occurrence and development through regulating multiple growth or apoptosis associated pathways or key biological molecules. Therefore, CRABP2 may be considered as a new diagnostic and prognostic marker for cancer, and a new therapeutic target for malignant tumors. Our present article summarizes the relationship between CRABP2 and tumor progression, drug resistance and prognosis, so as to provide reference for the future research.
