Effects of co-culture of dendritic cells loaded with MAGE-A3 antigen and cytokine-induced killer cells on tumor stem cells and malignant progression of endometrial cancer
10.12092/j.issn.1009-2501.2023.01.006
- Author:
Hao HUANG
1
;
Hong JIA
1
;
Xiaoshuang WANG
1
;
Lu ZHANG
2
;
Hua JIANG
3
Author Information
1. Department of Obstetrics and Gynecology, Chongqing Hospital of Traditional Chinese Medicine
2. Department of Ultrasound, Chongqing Hospital of Traditional Chinese Medicine
3. Department of Gynecology, The Third Affiliated Hospital of Chongqing Medical University
- Publication Type:Journal Article
- Keywords:
cytokine-induced killer cells;
dendritic cells;
endometrial cancer;
melanoma-associated antigen gene A3;
tumor stem cells
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(1):42-50
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effects of dendritic cells (DC) and cytokine-induced killer cells (CIK) carrying melanoma-associated antigen gene A3 (MAGE-A3) on endometrial cancer tumor stem cells and malignant progression. METHODS: Human peripheral blood was collected to separate mono-nuclear cells, and DC and CIK cells were induced by cytokines, respectively. DCs were incubated with MAGE-A3 and then co-cultured with CIK, and the phenotypes of DC-CIK and MAGE-A3-DC-CIK were detected by flow cytometry; The CD133
