Research progress of natural plant active ingredients in reversing tumor multidrug resistance by down-regulating P-gp
10.12092/j.issn.1009-2501.2023.03.012
- Author:
Shan LI
1
;
Yixin LIU
1
;
Feifei REN
1
;
Xiangchen LI
1
;
Zhiqing ZHANG
1
Author Information
1. The Second Hospital, Hebei Medical University
- Publication Type:Journal Article
- Keywords:
active ingredients;
natural plants;
P-gp;
reverse multidrug resistance;
tumor
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(3):331-340
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance (MDR) is the main factor of tumor recurrence and chemotherapy failure in clinical practice. Its mechanism is relatively complex, and one of the most thoroughly studied mechanism is the overexpression of P-glycoprotein (P-gp) on tumor cell membrane. Most of the chemotherapy drugs are p-gp substrates, and tumor cells will transport the chemotherapy drugs to the extracellular through p-gp mediated active transport, so that the concentration of effective drugs in the cell is reduced, resulting in drug resistance, leading to the decline of clinical efficacy. The reversal agent of P-gp can reduce the intracellular pumping of chemotherapeutic drugs by regulating the expression and transport activity of P-gp, and enhance the sensitivity of tumor cells to chemotherapeutic drugs, thus improving the therapeutic effect. In this paper, we will summarize the natural plant active ingredients that can reverse P-gp mediated MDR to provide reference for clinical and related studies.
