Application of quantitative pharmacology in vaccine research and development: overview and prospect
10.12092/j.issn.1009-2501.2023.03.010
- Author:
Guangli MA
1
;
Jing ZHANG
2
Author Information
1. Wuxi BioCity Biotechnology Co., Ltd
2. Phase I Clinical Research Center of Huashan Hospital Affiliated to Fudan University
- Publication Type:Journal Article
- Keywords:
dose response;
model based meta-analysis;
model informed drug development;
model informed vaccine development;
pharmacometrics;
quantitative system pharmacology;
vaccine
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(3):315-322
- CountryChina
- Language:Chinese
-
Abstract:
This article introduces the mechanism including antigen presentation, adjuvant, lymphatic system and the characteristics of vaccine, and then summarizes the key applications of core pharmacometrics approaches including QSP, PK/PD, dose response analysis, MBMA, in dose-response, preclinical and clinical translation, and correlation between biomarkers and efficacy of vaccines. It is expected that the successful application of model informed drug development can promote model informed vaccine development so that pharmacometrics makes its due contributions to the development of safer, more effective and more controllable vaccine products.
