Effects and mechanism of dapagliflozin on myocardial injury in type 1 diabetes mice

Author: Xuejiao ZHANG ¹ ; Jieting LIU ¹ ; Luxin LI ¹ ; Peijian CHEN ¹ ; Minglu DING ¹ ; Mengwei SUN ¹ ; Yanhui CHU ¹ ; Zhen ZHANG ²
Author Information

1. College of Life Sciences, Mudanjiang Medical University
2. The First Clinical Medical College, Mudanjiang Medical University
Publication Type:Journal Article
Keywords: cell apoptosis; dapagliflozin; diabetes; fibrosis; myocardial injury
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(3):257-265
CountryChina
Language:Chinese
Abstract: AIM: To investigate the effect of dapagliflozin on myocardial injury in type 1 diabetes mice and its mechanism. METHODS: Normal C57BL / 6J male mice were randomly divided into normal control group (Control), diabetes cardiomyopathy group (DCM) and dapagliflozin group (DAPA). The model of diabetes was induced by streptozotocin (STZ) and given maintenance feed. DAPA group was given 10 mg · kg