Research progress of lactate dehydrogenase A in digestive system tumors and related drugs
- Author:
Siyu WANG
1
;
Jiawei LI
1
;
Chenghao LI
1
;
Ling LI
1
;
Qingyang GUO
1
;
Lu QIU
1
;
Shiqin ZHOU
1
;
Yongqi LIU
1
;
Jiawei LI
2
;
Ling LI
2
;
Yongqi LIU
2
;
Jiawei LI
3
Author Information
- Publication Type:Journal Article
- Keywords: glycolysis; lactate dehydrogenase A; lactate metabolism; tumors of digestive system
- From: Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(4):445-454
- CountryChina
- Language:Chinese
- Abstract: Malignant tumors of digestive system are highly prevalent malignant tumors that seriously threaten human health around the world. At present, the curative efficacy and prognosis of traditional treatment methods cannot reach the expectation, so it is urgent to find new targets for cancer treatment and realize targeted therapy for tumors. Abnormal energy metabolism in tumor cells is regarded as a hallmark of cancer, and malignant tumor cells absorb glucose through aerobic glycolysis pathway, and obtain a small amount of energy and produce lactate under the catalysis of a series of enzymes. Lactate dehydrogenase A (Lactate dehydrogenase A, LDHA), as a key enzyme in the aerobic glycolysis pathway of tumor cells, plays an important role in the metabolic changes of tumor cells. Studies have demonstrated that LDHA has high expression characteristics in a variety of tumor cells,and its high expression in clinic is often related to the poor prognosis and high metastasis rate of tumors, which is expected to be a new target for cancer therapy. This article reviews the role of LDHA in the development of digestive system tumors and the research progress of related drugs.
