Advances in clinical research on drug-induced acute interstitial nephritis

Author: Mingkang ZHANG ¹ ; Yanrong MA ¹ ; Yongwen JIN ¹ ; Yan ZHOU ¹ ; Ruirui CUI ¹ ; Xin'an WU ¹ ; Mingkang ZHANG ² ; Ruirui CUI ² ; Xin'an WU ² ; Mingkang ZHANG ³ ; Yanrong MA ³ ; Yongwen JIN ³ ; Yan ZHOU ³ ; Ruirui CUI ³ ; Xin'an WU ³
Author Information

1. Department of Pharmacy, First Hospital of Lanzhou University
2. School of Pharmacy, Lanzhou University
3. Engineering Research Centre of Prevention and Control Risk for Clinical Medicine of Gansu Province
Publication Type:Journal Article
Keywords: clinical symptoms; drug-induced acute interstitial nephritis; induction drugs; pathogenesis; pathological features
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(4):419-428
CountryChina
Language:Chinese
Abstract: The kidneys are one of the main excretory organs for drugs and when drugs are not excreted effectively, they can accumulate in the kidneys or in the interstitial tubules, leading to drug-induced kidney injury. The tubulointerstitium accounts for 80% of the volume of the kidney and is the primary site of response to various types of renal injury. This article focuses on drug-induced acute interstitial nephritis, highlighting its clinical symptoms, listing common induction drugs, analysing pathological features, and explaining its pathogenesis from the perspective of immune response, with the aim of providing a basic and clinical evidence for subsequent studies.