Correlation between progesterone receptor G1978T polymorphism and endometrial cancer
10.12092/j.issn.1009-2501.2023.04.006
- Author:
Jing ZHOU
1
;
Chen ZHOU
1
;
Ke LIAO
1
;
Ailin QIU
1
;
Zifen GUO
1
;
Weilei DONG
2
;
Jing ZHOU
3
Author Information
1. Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical College, University of South China
2. Department of Obstetrics and Gynecology, the First Affiliated Hospital of University of South China
3. Department of Pharmacy, the First Affiliated Hospital of Shaoyang University
- Publication Type:Journal Article
- Keywords:
endometrial carcinoma;
G1978T polymorphism;
progesterone receptor
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(4):400-406
- CountryChina
- Language:Chinese
-
Abstract:
To explore the relationship between progesterone receptor (PGR) gene G1978T polymorphism and endometrial carcinoma. METHODS: After searching PubMed, EMBASE, Wan-fang and CNKI databases for literatures on PGR G1978T genotyping of endometrial cancer patients, the data were extracted and odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using STATA15. The whole blood samples of endometrial carcinoma cases (EC group) and normal women (control group) were collected. Allelic-specific primers matching G1978T wild type G allele and mutant type T allele were designed with 3' terminal phosphorothioate modification, and the two-directional primer extension was performed using Exo + polymerase to genotype PGR gene G1978T polymorphism and Sanger sequencing was used to verify the genotype. RESULTS: PGR gene G1978T mutation was marginally associated with endometrial carcinoma risk (ORper allele =1.10, 95%CI=0.98-1.24, P= 0.072). At the same time, only 1 normal blood samples were found with PGR gene G1978T mutation, and the differences in genotypes and allele frequency between the case group and the control group were not statistically significantP>0.05. CONCLUSION: The G1978T polymorphism of the PGR gene maybe not be associated with the risk of endometrial carcinoma.
