Progress in the prevention and treatment of traditional Chinese medicine based on the mechanism of intestinal injury of various chemotherapy

Shuang LI; Minghui Xiu; Xianqin DU; Jianzheng HE; Xingyao Lin; Shuang LI; Xianqin DU; Xingyao Lin; Shuzhen Han; Minghui Xiu; Jianzheng HE; Shuzhen Han; Jianzheng HE; Yuting Dai; Minghui Xiu

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Progress in the prevention and treatment of traditional Chinese medicine based on the mechanism of intestinal injury of various chemotherapy

Author: Shuang LI ¹ ; Minghui XIU ¹ ; Xianqin DU ¹ ; Jianzheng HE ¹ ; Xingyao LIN ¹ ; Shuang LI ² ; Xianqin DU ² ; Xingyao LIN ² ; Shuzhen HAN ³ ; Minghui XIU ³ ; Jianzheng HE ³ ; Shuzhen HAN ⁴ ; Jianzheng HE ⁴ ; Yuting DAI ⁵ ; Minghui XIU ⁵
Author Information

1. Provincial-level Key Laboratory for Molecular Medicine of Major Diseases, The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities
2. Gansu Research Center of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine
3. Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Universities, Gansu University of Traditional Chinese Medicine
4. School of Basic Medicine, Gansu Zhongshan University of Medicine
5. School of Public Health, Gansu University of Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: chemotherapy; intestinal injury; mechanism; prevention and treatment; traditional Chinese medicine
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(5):583-593
CountryChina
Language:Chinese
Abstract: Intestinal injury is a common adverse reaction of clinical chemotherapy drugs, which limits the further application of chemotherapy drugs and causes serious physical and mental burden to patients. At present, the mechanism of chemotherapy-induced intestinal injury is complex, and traditional Chinese medicine has an excellent preventive effect. This article reviews the related mechanisms of intestinal flora imbalance, oxidative stress, inflammatory response, cell apoptosis, and immune damage caused by chemotherapy, and summarizes the role of traditional Chinese medicine in prevention and treatment of oxidative stress, inflammatory response, cell apoptosis, and immune damage.