Optimization strategy of antibiotic dosing regimen in intensive care unit patients with augmented renal clearance

Zilong Dang; Wenyuan Cheng; Yuhui Wei; Xin'an WU; Zilong Dang; Haiyang Liu; Yangfan Zhang; Jinfeng Liu; Tianwei Zhang; Xin'an WU; Bin LI; Hong Guo; Xiaohui XU; Yile LI; Xin'an WU

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Optimization strategy of antibiotic dosing regimen in intensive care unit patients with augmented renal clearance

Author: Zilong DANG ¹ ; Wenyuan CHENG ¹ ; Yuhui WEI ¹ ; Xin'an WU ¹ ; Zilong DANG ² ; Haiyang LIU ² ; Yangfan ZHANG ² ; Jinfeng LIU ² ; Tianwei ZHANG ² ; Xin'an WU ² ; Bin LI ³ ; Hong GUO ³ ; Xiaohui XU ⁴ ; Yile LI ⁵ ; Xin'an WU ⁶
Author Information

1. Department of Pharmacy, The First Hospital of Lanzhou University
2. The First School of Clinical Medicine, Lanzhou University
3. Department of Critical Care Medicine, The First Hospital of Lanzhou University
4. Lanzhou Institute for Food and Drug Control
5. School of Pharmacy, Lanzhou University
6. Engineering Research Centre of Prevention and Control for Clinical Medication Risk
Publication Type:Journal Article
Keywords: antibacterial drugs; augmented renal clearance; intensive care unit patients; optimization strategy
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(5):561-571
CountryChina
Language:Chinese
Abstract: The incidence of augmented renal clearance (ARC) in intensive care patients (ICU) is exceptionally high, and these patients are often co-morbid with infection. The occurrence of ARC will significantly increase the clearance rate of antibiotics, making it difficult for conventional doses to reach effective therapeutic concentrations and affect the patient's anti-infective treatment effect and prognosis. It can be seen that it is crucial to formulate a reasonable dosing regimen for ICU patients with ARC. Regrettably, few reports in China about the adjustment strategy of antibiotic dosing regimens for ARC patients. Therefore, this article reviews the domestic and foreign literature for reference to provide evidence for medical personnel to adjust the dose of antibacterial drugs for such patients.