Diagnosis and individualized drug therapy for the rejection with hyperglycemia after liver Transplantation

Yining Chen; Yun Xiao; Xiaoyu Han; Lulu Huang; Hanbin Xiong; Yu FU; Baolin Wang; Jiangen AO; Jiake HE; Yining Chen; Yun Xiao; Xiaoyu Han; Lulu Huang; Jiake HE; Yining Chen; Yun Xiao; Xiaoyu Han; Lulu Huang; Jiake HE; Jingsheng MA; Xiaohui Guo; Lin Zhong; Jiake HE; Jiake HE

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Diagnosis and individualized drug therapy for the rejection with hyperglycemia after liver Transplantation

Author: Yining CHEN ¹ ; Yun XIAO ¹ ; Xiaoyu HAN ¹ ; Lulu HUANG ¹ ; Hanbin XIONG ¹ ; Yu FU ¹ ; Baolin WANG ¹ ; Jiangen AO ¹ ; Jiake HE ¹ ; Yining CHEN ² ; Yun XIAO ² ; Xiaoyu HAN ² ; Lulu HUANG ² ; Jiake HE ² ; Yining CHEN ³ ; Yun XIAO ³ ; Xiaoyu HAN ³ ; Lulu HUANG ³ ; Jiake HE ³ ; Jingsheng MA ⁴ ; Xiaohui GUO ⁴ ; Lin ZHONG ⁴ ; Jiake HE ⁴ ; Jiake HE ⁵
Author Information

1. Department of Pharmacy, The Second Affiliated Hospital of Nanchang University
2. Institute of Clinical Pharmacology, Nanchang University
3. School of Pharmacy, Nanchang University
4. Department of Organ Transplantation, The Second Affiliated Hospital of Nanchang University
5. Department of Pharmacy, Nanchang County People's Hospital
Publication Type:Journal Article
Keywords: hyperglycemia; individualized medicine; liver transplantation; rejection
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(5):550-555
CountryChina
Language:Chinese
Abstract: AIM: To establish individualized drug therapy strategy for patients with rejection and hyperglycemia after liver transplantation. METHODS: Clinical pharmacist collaborated with the surgeons and participated in the diagnosis and treatment of rejection and hyperglycemia after liver transplantation. Taking together liver function, therapeutic drug monitoring, drug-drug interactions between tacrolimus and wuzhi capsule, individualized drug therapy was adapted to improve the prognosis. RESULTS: The patient recovered well and survived in good health till now. CONCLUSION: It is highly suggested that clinical pharmacists actively involved in treatment of more severe and difficult-to-treat disease and design the individualized dosing regimens. This will largely contribute in reduced adverse drug reaction, improved safety and effectiveness in drug use as well as the quality of life in the "post-transplantation era".