Mechanism of neuroprotective effect of ginsenoside Rg1 regulating Epac1/Rap1 signaling pathway in rats with ischemic stroke
10.12092/j.issn.1009-2501.2023.07.001
- Author:
Kun WANG
1
;
Sheng LU
1
;
Peipei XU
2
;
Lanlan ZHOU
3
Author Information
1. Department of Pharmacy, First Affiliated Hospital of Huzhou University
2. Department of Laboratory Medicine, First Affiliated Hospital of Huzhou University
3. Department of Pharmacology, Anhui Medical University
- Publication Type:Journal Article
- Keywords:
Epac1;
ginsenoside Rg1;
ischemic stroke;
neuroprotection
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(7):721-727
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the neuroprotective effect of ginsenoside Rg1 on rats with ischemic stroke and to investigate its mechanism of action. METHODS: Eighty-four SPF-grade SD male rats at about 13 weeks of age were randomly divided into 7 groups (n=12): sham-operated group, model group, Rg1 low-dose group, Rg1 medium-dose group, Rg1 high-dose group, Epac1 agonist group, and Epac1 inhibitor group. The model group, Rg1 low, medium and high dose groups, Epac1 agonist group and Epac1 inhibitor group were all used to establish a permanent focal cerebral ischemia rat model. Rats in the Rg1 low, medium and high dose groups were treated with 60, 120 and 240 μmol/L Rg1 administered by gavage at a fixed time every morning. The rats in the Epac1 agonist and Epac1 inhibitor groups were administered intraperitoneally at a fixed time each morning with a concentration of 1.0×10
