Effect of augmented renal clearance (ARC) on the pharmacokinetics, efficacy, and safety of vancomycin in patients with infective endocarditis
10.12092/j.issn.1009-2501.2023.10.007
- Author:
Lili WU
1
;
Yan WANG
1
;
Zhi LIANG
2
;
Siyong HUANG
3
Author Information
1. Department of Pharmacy, The First People's Hospital of Foshan
2. Department of Clinical Pharmacy, Guangzhou First People's Hospital, South China University of Technology
3. Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
ARC;
infective endocarditis;
pharmacokinetics;
therapeutic drug monitoring;
vancomycin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(10):1139-1145
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of augmented renal clearance (ARC) on vancomycin pharmacokinetics, efficacy, and safety in patients with infective endocarditis, so as to provide better guidance for vancomycin medication. METHODS: The retrospective analysis was conducted. Patients data from the hospital medical record system from April 2020 to April 2023 during the cardiovascular surgery with use of vancomycin were collected. The subjects were divided into normal group and ARC group according to glomerular filtration rate (eGFR). According to the population pharmacokinetic model, the measured trough concentration was used for a Bayesian approach to estimate individual pharmacokinetic parameters and analyze influence of ARC on vancomycin pharmacokinetics. RESULTS: A total of 163 patients were included in this study. The incidence of ARC was 23.31%. The age of patients in ARC group was significantly lower than that in normal group (P<0.05). Moreover, the steady-state trough concentration (Cmin), trough concentration compliance rate, area under the curve (AUC), and elimination half life (t1/2) were significantly lower in ARC group than that in normal group (P<0.05). In addition, ARC group had significantly higher clearance (CL) and elimination rate than normal group (P<0.05). Correlation analysis showed that Cmin was positively correlated with AUC (r
