Trimethylamine N-oxide: a potential target for osteoporosis treatment

Author: Yangting ZHAO ¹ ; Chongyang CHEN ¹ ; Binjing PAN ¹ ; Xiaoyu LV ¹ ; Jingfang LIU ¹ ; Yangting ZHAO ² ; Chongyang CHEN ² ; Binjing PAN ² ; Xiaoyu LV ² ; Jingfang LIU ²
Author Information

1. The First Clinical Medical College, Lanzhou University
2. Department of Endocrinology, the First Hospital of Lanzhou University
Publication Type:Journal Article
Keywords: bone mineral density; fracture; intestinal flora; osteoporosis; trimethylamine N-oxide
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(10):1161-1167
CountryChina
Language:Chinese
Abstract: Trimethylamine N-oxide (TMAO) is an intestinal flora metabolite produced in the liver by the oxidation of trimethylamine (TMA) by hepatic enzymes. Recently, it has been found that plasma TMAO levels play an important role in the development and progression of osteoporosis. This review has presented the physiological functions and metabolic processes of TMAO, and its effects on the development and progression of osteoporosis through oxidative stress and inflammation. Plasma TMAO levels are influenced by diet as well as medications, which provides a new perspective and target for the treatment and prevention of osteoporosis.