Research progress on the role of melatonin in the treatment of ischemia-reperfusion injury
10.12092/j.issn.1009-2501.2023.12.011
- Author:
Xuelei JIN
1
;
Yapeng LU
1
;
Xuerui DI
1
;
Qihui ZHENG
1
;
Yisa SHI
1
Author Information
1. Department of Anestheiology, Lanzhou University Second Hospital
- Publication Type:Journal Article
- Keywords:
ischemia reperfusion injury;
melatonin;
organ protection
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(12):1409-1414
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion (I / R) is a complex hemodynamic process that can cause tissue damage through oxidative stress, mitochondrial dysfunction, and inflammatory reactions. It is an important factor leading to poor prognosis in patients, and the exploration of effective prevention and treatment measures is of significant clinical significance. As an endogenous hormone with strong antioxidant and anti-inflammatory properties, Melatonin plays an important role in reducing cell death and improving tissue I / R injury. Therefore, this article reviews the relationship between Melatonin and organ I/R injury in order to provide a theoretical basis for the clinical application of melatonin to alleviate organ I/R injury.
