Hederagenin improves psoriasis skin lesions by inhibiting macrophage mincle-mediated inflammation
10.12092/j.issn.1009-2501.2023.12.003
- Author:
Xinyu HE
1
;
Xia ZHONG
2
;
Ruizhi TAN
2
;
Peng LIU
3
Author Information
1. Southwest Medical University
2. Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University
3. Beijing Traditional Chinese Medicine Hospital Shunyi Hospital
- Publication Type:Journal Article
- Keywords:
hederagenin;
inflammation;
macrophage;
mincle;
psoriasis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(12):1339-1346
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects and mechanisms of hederagenin (HDG) in improving psoriasis skin lesions and inflammation in mice. METHODS: A mouse model of psoriasis was established by depilation of the back and continuous application of imiquimod for 7 days in C57 mice. After modeling, HDG was administered orally (low dose: 25 mg · kg
