Molecular mechanism of high altitude hypoxia induced intestinal homeostasis imbalance and research progress of traditional Chinese medicine

Qian Kang; Minghui Xiu; Dan Yang; Jianzheng HE; Hongxia Gong; Wangjie Cao; Yun SU; Minghui Xiu; Jianzheng HE; Hongxia Gong; Wangjie Cao; Yun SU; Qian Kang; Dan Yang; Jianzheng HE; Hongxia Gong; Wangjie Cao; Yun SU; Minghui Xiu; Xueyan Zhang; Shuwei Wang

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Molecular mechanism of high altitude hypoxia induced intestinal homeostasis imbalance and research progress of traditional Chinese medicine

Author: Qian KANG ¹ ; Minghui XIU ¹ ; Dan YANG ¹ ; Jianzheng HE ¹ ; Hongxia GONG ¹ ; Wangjie CAO ¹ ; Yun SU ¹ ; Minghui XIU ² ; Jianzheng HE ² ; Hongxia GONG ² ; Wangjie CAO ² ; Yun SU ² ; Qian KANG ³ ; Dan YANG ³ ; Jianzheng HE ³ ; Hongxia GONG ³ ; Wangjie CAO ³ ; Yun SU ³ ; Minghui XIU ⁴ ; Xueyan ZHANG ⁴ ; Shuwei WANG ⁴
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1. Gansu University of Traditional Chinese Medicine, Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Province
2. Provincial-level Key Laboratory for Molecular Medicine of Major Diseases, the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities
3. Gansu Zhongshan University of Medicine, School of Basic Medicine
4. Gansu University of Traditional Chinese Medicine, School of Public Health
Publication Type:Journal Article
Keywords: anti-hypoxia; high-altitude hypoxia; inflammation; intestinal homeostasis imbalance; oxidative damage
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(12):1391-1402
CountryChina
Language:Chinese
Abstract: Hypoxia is one of the factors restricting the survival of people at high altitudes, which can cause various symptoms such as vomiting, diarrhea, palpitations, shortness of breath and acute coma. About 80% of patients with acute mountain sickness have at least one symptom of a gastrointestinal distress (e. g., anorexia, nausea, diarrhea, vomiting, etc.). The pathological characteristics, pathogenesis and drug treatment of intestinal injury caused by high-altitude hypoxia were studied, which is conducive to the diagnosis and treatment of plateau gastrointestinal diseases. Therefore, by summarized relevant literature and systematically expounds the related researches on intestinal damage caused by high altitude hypoxia. We summarized the changes of intestinal morphology, intestinal cells, intestinal flora and other intestinal homeostasis caused by high altitude hypoxia, the mechanism of intestinal inflammation and oxidative damage, and the treatment of traditional Chinese medicine, which provide reference and information for reference for scientific research workers and clinicians.