Research progress of pharmacologic therapy in obstructive sleep apnea
10.12092/j.issn.1009-2501.2024.02.012
- Author:
Xingdong WU
1
;
Hongmei YUE
1
;
Haobin ZHU
1
;
Miaomiao LIU
1
;
Yating LI
1
;
Jinhui XU
1
;
Hongmei YUE
2
Author Information
1. The First Clinical College, Lanzhou University
2. Department of Respiratory and Critical Care Medicine, The First Hospital of Lanzhou University
- Publication Type:Journal Article
- Keywords:
obstructive sleep apnea;
pathophysiological mechanism;
pharmacologic therapy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(2):215-229
- CountryChina
- Language:Chinese
-
Abstract:
Obstructive sleep apnea (OSA) is a common sleep disordered breathing disorder. As a major global public health problem, untreated OSA can lead to a variety of adverse health outcomes, including various cardiovascular and cerebrovascular diseases, metabolic disorders, and psychiatric disorders such as anxiety and depression. Traditional OSA therapies such as positive airway pressure (PAP), weight loss, oral appliance, upper airway surgery, and postural therapy focus on the anatomical factors of OSA. However, the pathogenesis of OSA is heterogeneous, and non-anatomical factors also play an important role in most patients. Although there is no drug with exact efficacy for the treatment of OSA, with the deepening understanding of the pathophysiological mechanism of OSA, more and more clinical studies are devoted to the study of drug treatment of OSA and its complications, and a series of results have been achieved. The following is a review of the relevant studies on drug treatment of OSA in recent years, hoping to provide literature support and theoretical basis for future research on drug treatment of OSA.
