Novel mechanisms driving renal tubulointerstitial fibrosis
10.12092/j.issn.1009-2501.2024.03.014
- Author:
Yanni ZHANG
1
;
Yuxin DUAN
1
;
Yi BAI
1
;
Jinyao YU
1
;
Jiayi SUN
1
;
Zejie WANG
1
;
Ling LI
1
;
Qifa YE
1
Author Information
1. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation
- Publication Type:Journal Article
- Keywords:
chronic kidney diseases;
tubular epithelial cells;
tubulointerstitial fibrosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(3):348-353
- CountryChina
- Language:Chinese
-
Abstract:
Renal fibrosis, especially tubulointerstitial fibrosis, is the most common pathway of all chronic kidney diseases progressing to end-stage renal diseases. Several adaptive reactions occur in renal tubular epithelial cells after chronic injury, such as changes in glycolipid metabolism, unfolded protein response, autophagy and senescence, epithelial-to-mesenchymal transition and G2/M cell cycle arrest. Maladaptive repair mechanisms can induce tubulointerstitial fibrosis. This article will discuss the molecular mechanism of these adaptive responses of renal tubular epithelial cells driving renal tubulointerstitial fibrosis, and provide a basis for exploring new drug targets for renal tubulointerstitial fibrosis.
