The application of positron emission tomography in the research and development of central nervous system drugs

Author: Size LI ¹ ; Xiaojie WU ¹ ; Jing ZHANG ¹ ; Qi HUANG ² ; Yihui GUAN ² ; Fang XIE ² ; Qi HUANG ³ ; Yihui GUAN ³ ; Fang XIE ³ ; Shaonan WANG ⁴ ; Jing ZHANG ⁵
Author Information

1. Phase I Clinical Research Center, Huashan Hospital, Fudan University
2. Department of Nuclear Medicine, PET Center, Huashan Hospital, Fudan University
3. National Center for Neurological Disorders (Huashan)
4. Translational Medicine & Clinical Pharmacology, Boehringer Ingelheim, The Chinese Market
5. Institue of Antibiotics, Huashan Hospital, Fudan University
Publication Type:Journal Article
Keywords: central nervous system; pharmacokinetics; positron emission tomography; receptor occupancy; the research and development of new drugs
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2024;29(3):316-327
CountryChina
Language:Chinese
Abstract: Positron emission tomography (PET) now plays an important role in the research and development (R&D) of central nervous system (CNS) drugs. PET could characterize the biodistribution, pharmacokinetics, and receptor binding of CNS drugs quantitatively. The present review summarized the quantitative methods of PET used in the pharmacokinetics and receptor occupancy analysis of CNS drugs. Moreover, the present review listed various applications of PET supporting R&D of CNS drugs, which could provide a new direction for the R&D of CNS drugs.