Mechanism and treatment of mucous hypersecretion in chronic obstructive pulmonary disease
10.12092/j.issn.1009-2501.2024.04.004
- Author:
Ting ZHANG
1
;
Rong SUN
1
;
Yong YANG
1
;
Weichun LIU
1
;
Yuping YUAN
1
;
Xu JU
1
;
Qian WANG
1
Author Information
1. Department of Pulmonary and Critical Care Medicine, Zhabei Central Hospital in Shanghai Jing'an District
- Publication Type:Journal Article
- Keywords:
chronic mucus hypersecretion;
chronic obstructive pulmonary disease;
mechanism;
treatment
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(4):383-391
- CountryChina
- Language:Chinese
-
Abstract:
Airway mucus hypersecretion is one of the important pathophysiological and clinical manifestations of chronic obstructive pulmonary disease. It has been reported in the literature that COPD patients with chronic airway mucus hypersecretion have more frequent acute exacerbations, more severe lung function decline, and higher hospitalizations and mortality. Therefore, it is particularly critical to understand the pathogenesis of hypersecretion of mucus in chronic obstructive pulmonary disease and find out effective treatment. This article focuses on the structure, significance of airway mucus and the mechanism of hypersecretion of mucus in chronic obstructive pulmonary disease (COPD). In addition, we also summarized drug and non-drug therapy for chronic airway mucus hypersecretion in this article. Drug therapy includes traditional drug therapy, some new targeted drug therapy for pathogenesis and traditional Chinese medicine therapy, and non-drug therapy includes smoking cessation, physical therapy and bronchos-copy therapy. We hope that it will provide new ideas and directions for the treatment of mucus hypersecretion in COPD patients.
