Effect of Vaccarin on atherosclerosis in mouse model and its mechanism
- Author:
Xin-Yu MA
1
;
Fei XU
1
;
Lei-Lei GONG
1
;
Rui-Tang CHENG
1
;
Sun-Han MIAO
1
;
Yu-Wei ZHU
1
;
Wei-Wei CAI
1
;
Bao HOU
1
;
Li-Ying QIU
1
Author Information
- Publication Type:Journal Article
- Keywords: atherosclerosis; inflammatory factor; lipid deposition; plaque fibrosis; ROS/p38 MAPK; vaccarin
- From: Chinese Pharmacological Bulletin 2021;37(11):1518-1523
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effect of vaccarin on mouse atherosclerosis in vivo and the underlying mechanism. Methods AopE mice aged 6 to 8 weeks old were used to establish the atherosclerosis model. Oil red O staining was used to determine the lipid levels in aorta and aortic root. Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of serum inflammatory factors. Results Vaccarin could effectively reduce the levels of blood glucose and blood pressure in AopE
