CP-25 inhibits Thl7 cell differentiation and improves kidney injury in MRL/lpr lupus mice

Author: Li-Na HUANG ¹ ; Sheng-Fu WANG ¹ ; Xiang WANG ¹ ; Liang XU ¹ ; Xiao-Yang YUAN ¹ ; Jia-Jie KUAI ¹ ; Wei WEI ¹ ; Shang-Xue YAN ¹
Author Information

1. Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Team of Anti-inflammatory and Immunological Medicine Science and Technology Innovation, Anhui Universities
Publication Type:Journal Article
Keywords: CP-25; MRL/lpr mice; ROR-γt; STAT3; systemic lupus erythematosus; Thl7 cells
From: Chinese Pharmacological Bulletin 2021;37(7):965-972
CountryChina
Language:Chinese
Abstract: Aim: To explore the role of paeoniflorin-6'- O-benzenesulfonate (CP-25) in MRL/lpr mice and the regulating action on Thl7 cell differentiation. Methods MRL/lpr mice were randomly assigned to five groups as follows; model group, CP-25 (20, 40, 80 mg · kg