Averrhoa Carambola L. Roots DMDD alleviates myocardial injury in diabetes mellitus mice by regulating ROS-mediated autophagy pathway

Author: Jing MA ¹ ; De-Lun HUANG ¹ ; Yan-Ping ZHOU ¹ ; Liu-Ting HOU ¹ ; Ya-Kun LI ¹ ; Jing ZHONG ¹ ; Xiao-Jie WEI ¹ ; Ya-Ni WU ²
Author Information

1. College of Basic Medical, Guangxi University of Chinese Medicine
2. Pharmaceutical College, Guangxi Medical University
Publication Type:Journal Article
Keywords: autophagy; Averrhoa Carambola L. Roots DMDD; diabetes mellitus; myocardial injury; PBK/Akt/mTOR pathway; ROS
From: Chinese Pharmacological Bulletin 2021;37(6):823-827
CountryChina
Language:Chinese
Abstract: Aim To evaluate the protective effect of Averrhoa Carambola L. Roots DMDD alleviating myocardial injury in diabetes mellitus (DM) mice and its mechanism. Methods SD mice were given high-glucose-high-fat diet combined with streptozotocin to induce DM model, and were administered with DMDD. The fasting blood glucose (FBG) was recorded. The left ventricular end-diastolic pressure (LVEDP), left ventricular systolic pressure (LVSP), maximum upstroke velocity of left ventricular pressure (+ dp/dt