Advances on protective effects of gypenosides on neural disorders and underlying mechanisms
10.3969/j.issn.1001-1978.2021.06.006
- Author:
Ya-Nan GENG
1
;
Ming ZHAO
1
;
Ming FAN
1
;
Ling-Ling ZHU
1
;
Ya-Nan GENG
2
;
Ming FAN
2
Author Information
1. Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences
2. Beijing Institute for Brain Disorders, Capital Medical University
- Publication Type:Journal Article
- Keywords:
gypenosides;
inflammation;
neural disorders;
neurogenesis;
oxidative stress;
pathogenesis
- From:
Chinese Pharmacological Bulletin
2021;37(6):765-768
- CountryChina
- Language:Chinese
-
Abstract:
Gypenosides (GP), the main medicinal ingredient of Gynostemma Pentaphyllum Makino, exhibits excellent protective effect on various neural diseases through several mechanisms, including anti-inflammation, anti-oxidative stress and pro-neural regeneration. In the current review, we have made a summary on the research progress of GP on neural disorders, like Alzheimer' s disease, Parkinson' s disease, depression, hypoxic brain injury and so on, aiming to provide an experimental basis for the further research and drug development of GP.
