Research progress on regulation of PGC-lα in obesity-related metabolic diseases
10.3969/j.issn.1001-1978.2021.06.001
- Author:
Quan-Quan ZHANG
1
;
Hong QIN
1
Author Information
1. Dept of Nutrition and Food Hygiene, Xiangya School of Public Health, Central South University
- Publication Type:Journal Article
- Keywords:
hyperlipidemia;
hypertension;
metabolic diseases;
obesity;
peroxisome proliferator-activated receptor γ coactivator 1-alpha;
type II diabetes
- From:
Chinese Pharmacological Bulletin
2021;37(6):741-745
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferator-activated receptor γ coactivator 1-alpha (PGC-1α) is a member of superfamily of transcriptional co-regulators. It was first discovered to be related to the adaptive thermogenesis of brown adipose tissue. Later, it has been discovered that PGC-la can also regulate glucose and lipid metabolism and vascular endothelial function, thus influence the occurrence and development of obesity-related metabolic diseases such as hyperlipidemia, type II diabetes and hypertension. Drugs targeting PGC-1α are promising for the prevention and treatment of these diseases. Here we review the research progress on regulation of PGC-1α in obesity related metabolic diseases, aiming to provide theoretical basis for the development of drugs targeting PGC-1α.
