The therapeutic effect of salidroside on rats with permanent cerebral ischemia through regulating PDK/Akt signaling pathway
- Author:
Jia-Hui HUANG
1
;
Chun-Rui ZHAO
1
;
Jing-Wen NIE
1
;
Rui LUO
1
;
Si-Ying HUANG
1
;
Chun-Xiao SUN
1
;
Ze-Lin YANG
1
;
Xiong YING
1
;
Gui-Zhu HONG
1
;
Wen-Fang LAI
1
Author Information
- Publication Type:Journal Article
- Keywords: NeuN; neuroprotection; NF-κB p50; PBK/Akt signaling pathway; pMCAO; salidroside
- From: Chinese Pharmacological Bulletin 2021;37(5):698-703
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the neuroprotective effect and mechanism of salidroside (Sal) on rats with permanent middle cerebral artery occlusion model (pMCAO) by regulating the PI3 K/AKT signaling pathway. Methods A total of 80 healthy adult SPF male SD rats were randomly divided into sham operation group (sham group), model group (pMCAO group), drug administration group (pMCAO + Sal group) and inhibitor group (pMCAO + Sal + YL group). After the pMCAO model rats were prepared by the line bolt method, salidroside (50 mg · kg
