Effect of Exendin-4 on endothelial progenitor cell function and AKT/eNOS signaling pathway in a mouse model of type 1 diabetes

Author: Qing-Yun SHUAI ¹ ; Zheng CAO ¹ ; Qing-Yun SHUAI ² ; Qiang TU ² ; Xiao-Chuan HUANG ² ; Jie FU ² ; Zheng CAO ²
Author Information

1. Hubei University of Medicine, Taihe Hospital
2. Dept of Cardiology, Taihe Hospital
Publication Type:Journal Article
Keywords: AKT/eNOS signaling pathway; diabetes; endothelial progenitor cells; Exendin-4; glucagon-like peptide-1 receptor; vasculogenesis
From: Chinese Pharmacological Bulletin 2021;37(5):693-698
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of Exendin4 on proliferation, migration, adhesion and senescence of endothelial progenitor cells (EPCs) in type I diabetic mice and its possible mechanism. Methods EPCs from 6-month diabetic mice were isolated and cultured by density gradient centrifugation. Cells were treated with different concentrations of Exendin-4 (1, 5, 10, 25 μmol · L