Quercetin promotes apoptosis of breast cancer cells by targeting GAS5/Notchl signaling pathway
10.3969/j.issn.1001-1978.2021.05.009
- Author:
Duo-Chen JIANG
1
;
Le JIN
1
;
Jing JU
1
;
Hong-Xiao CHEN
2
;
Lei ZHANG
2
;
Zhao-Lin CHEN
2
Author Information
1. Anqing Hospital Affiliated to Anhui Medical University
2. Dept of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Anhui Provincial Hospital
- Publication Type:Journal Article
- Keywords:
apoptosis;
breast cancer;
long non-coding RNA GAS5;
Notchl signaling pathway;
Quercetin;
targeting
- From:
Chinese Pharmacological Bulletin
2021;37(5):637-644
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the possible mechanism of quercetin in promoting apoptosis of breast cancer cells. Methods Breast cancer cells MCF-7 were treated with quercetin. Cell viability was detected by MTT assay, cell proliferation and cloning ability were measured by plate colony formation assay, and cell apoptosis was examined by Annexin V-FITC/PI double staining assay. Meanwhile, MCF-7 cells were treated with quercetin (40, 80, 160 μmol · L
