Sacubitril/valsartan reduces susceptibility of atrial fibrillation by reversing structural remodeling of atrial in spontaneously hypertensive rats
- Author:
Qian LI
1
;
Xin LI
1
;
Lu-An LI
1
;
Hui-Shan ZHOU
1
;
De-Wei PENG
1
;
Chun-Yu DENG
1
;
Fang RAO
1
;
Shu-Lin WU
1
;
Qian LI
2
;
Xin LI
2
;
Lu-An LI
2
;
Hui-Shan ZHOU
2
;
De-Wei PENG
2
;
Meng-Zhen ZHANG
2
;
Zhao-Yu WANG
2
;
Su-Juan KUANG
2
;
Chun-Yu DENG
2
;
Fang RAO
2
;
Shu-Lin WU
2
Author Information
- Publication Type:Journal Article
- Keywords: atrial fibrillation; fibrosis; renin-angiotensin system; sacubitril/valsartan; spontaneously hypertensive rats; valsartan
- From: Chinese Pharmacological Bulletin 2021;37(5):631-637
- CountryChina
- Language:Chinese
- Abstract: Aim To observe the effects of sacubitril/valsartan (Sac/Val, LCZ696) on atrial remodeling and atrial fibrillation (AF) susceptibility in spontaneously hypertensive rats (SHR). Methods Twenty-four 7-week-old male SHR were randomly divided into SHR group, SHR + Val group (30 mg · kg
