Mechanism of PSMD10 in homocysteine activating hepatocyte autophagy and promoting liver injury

Author: Xin-Yan WU ¹ ; Qing-Qing WANG ¹ ; Long XU ¹ ; Hui ZHANG ¹ ; Wei GUO ¹ ; An-Ning YANG ¹ ; Yi-Deng JIANG ¹ ; Xin-Yan WU ² ; Qing-Qing WANG ² ; Long XU ² ; Hui ZHANG ² ; Wei GUO ² ; An-Ning YANG ² ; Yi-Deng JIANG ² ; Xin-Yan WU ³ ; Qing-Qing WANG ³ ; Long XU ³ ; Hui ZHANG ³ ; Wei GUO ³ ; An-Ning YANG ³ ; Yi-Deng JIANG ³ ; Yun JIAO ⁴ ; Yin-Ju HAO ⁵
Author Information

1. School of Basic Medicine, National Health Commission, Ningxia Medical University, Ningxia Hui Autonomous Region
2. Key Lab of Metabolic Cardiovascular Disease Research, National Health Commission, Ningxia Medical University, Ningxia Hui Autonomous Region
3. Ningxia Key Lab of Vascular Injury and Repair Research, Ningxia Medical University, Ningxia Hui Autonomous Region
4. Dept of Infection, Ningxia Medical University, Ningxia Hui Autonomous Region
5. School of Pharmacy, Ningxia Medical University, Ningxia Hui Autonomous Region
Publication Type:Journal Article
Keywords: ALT; AST; autophagy; Hcy; hepatocyte; liver injury; PSMD10
From: Chinese Pharmacological Bulletin 2021;37(4):535-541
CountryChina
Language:Chinese
Abstract: Aim To discuss the mechanism of proteasome 26S subunit non-ATPase 10(PSMD10) activating hepatocyte autophagy and promoting liver injury by in homocysteine. Methods Wild mice and cystathionine β-synthase (CBS) gene knockout mice were used and divided into normal (cbs