Arctigenin attenuates airway inflammation in asthmatic mice via SIRT1/NLRP3 pathway

Author: Yi-Hua PIAO ¹ ; Yi-Hua PIAO ² ; Yi-Lan SONG ² ; Zhi-Guang WANG ² ; Jing-Zhi JIANG ² ; Liang-Chang LI ² ; Hong-Mei PIAO ² ; Guang-Hai YAN ² ; Yi-Lan SONG ³ ; Jing-Zhi JIANG ³ ; Liang-Chang LI ³ ; Guang-Hai YAN ³ ; Zhi-Guang WANG ⁴ ; Hong-Mei PIAO ⁴
Author Information

1. Dept of Critical Care Medicine, Hospital of Yanbian University
2. Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases, Yanbian University
3. Dept of Anatomy, College of Medicine, Yanbian University
4. Respiratory Dept of Respiratory and Critical Care Medicine, Hospital of Yanbian University
Publication Type:Journal Article
Keywords: airway inflammation; arctigenin; asthma; cytokine; NLRP3; SIRT1
From: Chinese Pharmacological Bulletin 2021;37(4):498-504
CountryChina
Language:Chinese
Abstract: Aim To investigate the efficacy of arctigenin on airway inflammation in a mouse model of asthma and the mechanism related to the SIRT1/NLRP3 signaling pathway. Methods Forty female BALB/c mice of clean grade were selected and divided into control group, OVA model group and ATG group (5, 10 and 20 mg · kg