Research progress of JMJD3 in Parkinson's disease
10.3969/j.issn.1001-1978.2021.04.003
- Author:
Xiao-Ni SHAO
1
;
Mei-Wei WU
1
;
Peng-Ke HE
1
Author Information
1. College of Pharmacy, Southwest Minzu University
- Publication Type:Journal Article
- Keywords:
dopaminergic neurons;
H3K27me3;
JMJD3;
microglia;
Parkinson's disease
- From:
Chinese Pharmacological Bulletin
2021;37(4):455-458
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease is a common neurodegenerative disease in middle-aged and elderly people, in which the pathogenic factors are not yet clear. Genetics, dietary habits, environmental toxins, immunological abnormalities, inflammation and oxidative stress response, apoptosis, and mitochondrial dysfunctions which caused by a variety of physiological and biogenic changes are likely to exacerbate the occurrence of Parkinson's disease. In recent years, studies have shown that the activity of microglia is closely related to Parkinson's disease, and that the active microglia can promote the release of inflammatory factors, while the differentiation of dopamine neurons in the substantial nigra of midbrain area is also closely related to Parkinson's disease. As a histone H3K27me3 demethylase, JMJD3 is involved and affects the activity of microglia, which can regulate the polarization of microglia as well and affect the survival of dopaminergic neurons in the mesencephalon. This provides new methods and strategies for treating Parkinson' s disease. This paper summarizes the structure and function of JMJD3, as well as its role in neuro-inflammation mediated by microglia and its effect on neurons, and explores the functions and related research progress of JMJD3 in Parkinson's disease.
