The anti-tumour mechanism of Shuanghuang Qizhen Keliu Prescription based on network pharmacology
10.3969/j.issn.1001-1978.2021.09.021
- Author:
Xiao-Na LANG
1
;
Yu-Ling QIU
1
;
De-Xin KONG
1
;
Xiao-Na LANG
2
Author Information
1. School of Pharmacy, Tianjin Medical University
2. Dept of Pharmacy, Tianjin Hospital
- Publication Type:Journal Article
- Keywords:
Astragalus mem-branaceus;
Ganoderma lucidum;
ligu-strum lucidum;
lycium chinensis;
network pharmacology;
polygonati rhizome;
tumor
- From:
Chinese Pharmacological Bulletin
2021;37(9):1311-1317
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the anti-tumour mechanism of Shuanghuang Qizhen Keliu Prescription based on network pharmacology. Methods The active components and targets of Shuanghuang Qizhen Keliu Prescription were searched and selected through the TCM-SP database. Related targets of tumor were screened and retrieved by OMIM. The key anti-tumor targets of Shuanghuang Qizhen Keliu Prescription were obtained by using Venn diagram analysis. The key target PPI network was constructed and the key targets were obtained by Cytoscape. Metascape platform was used for GO and KEGG enrichment analysis of key targets. Results There were many active components such as quercetin, kaempferol, and beta-sitosterol in Shuanghuang Qizhen Keliu Prescription, and their targets might be TP53, AKT1, JUN, MAPK1, TNF, RELA, IL-6 and so on. The anti-tumour mechanism might be proliferation inhibition, migration inhibition and apoptosis promotion. Conclusions This study preliminarily discusses the potential anti-tumour mechanism of Shuanghuang Qizhen Keliu Prescription, providing ideas and basis for subsequent experimental research.
