Effect of Li-Zhong-Tang on gastric ulcer in rats based on Raf/MEK/ERK signaling pathway and its mechanism

Author: Hou-Pan SONG ¹ ; Xiao-Juan CHEN ¹ ; Xin-Yi CHEN ¹ ; Jing-Yue QIU ¹ ; Man-Ting WU ¹ ; Hou-Pan SONG ² ; Xiao-Juan CHEN ² ; Xin-Yi CHEN ² ; Jing-Yue QIU ² ; Man-Ting WU ² ; Hou-Pan SONG ³ ; Qing-Hua PENG ³ ; Mei-Yan ZENG ⁴
Author Information

1. Hunan Provincial Key Laboratory of Diagnostic Research in Chinese Medicine
2. Key Laboratory of TCM Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy
3. Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases
4. Hunan Provincial Key Laboratory of Translational Research in TCM Prescriptions and Zheng, Hunan University of Chinese Medicine
Publication Type:Journal Article
Keywords: gastric acid; gastric ulcer; inflammatory mediators; Li-Zhong-Tang; pepsin; signaling pathway; spleen-stomach vacuity cold syndrome
From: Chinese Pharmacological Bulletin 2021;37(9):1291-1298
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of Li-Zhong-Tang (LZT) in the treatment of gastric ulcer (GU) with pattern of spleen-stomach vacuity cold in rats based on Raf/MEK/ERK signaling pathway and the underlying molecular mechanism. Methods SD rats were randomly divided into normal group, GU model group, esomeprazole (ESO) group, LZT low dose and high dose groups. The morphological changes of gastric mucosa were observed by naked eyes and HE staining. The activities of gastric acid and pepsin were measured. The contents of prostaglandin E