Mechanism of total C-21 steroidal glucosides from root of Cynanchum auriculatum in activation of human hepatic stellate cells via TGF-β

Author: Ting ZHANG ¹ ; Yong-Fang DING ¹ ; Yun-Ru PENG ¹ ; Ting ZHANG ² ; Yong-Fang DING ² ; Yun-Ru PENG ²
Author Information

1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine
2. Jiangsu Province Academy of Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: Cynanchum auriculatum; fibrosis; human hepatic stellate cells; Nf-κB; Smad; TGF-β; α-SMA
From: Chinese Pharmacological Bulletin 2021;37(9):1231-1236
CountryChina
Language:Chinese
Abstract: Aim To investigate the inhibitory effect of total C-21 steroidal glucosides (TCSG) from the root of Cynanchum auriculatum on activation of human hepatic stellate cells and the underlying mechanism. Methods The fibrosis model in vitro was established by treating LX-2 cells with TGF-β