Protective effects of proanthocyanidins from Rubus amabilis Focke on pancreatic tissues of diabetic mice

Author: Jian FANG ¹ ; Jin-Zhi TONG ¹ ; Yu-Fan YANG ¹ ; Jian-Hui ZHANG ¹ ; Tian-Tian ZHU ¹ ; Jiao-Jiao SHANG ¹ ; Min SUN ¹ ; Gui-Xing ZHU ² ; Li TONG ³
Author Information

1. School of Life Sciences, Anhui University
2. Dept of Pathology, Yingshang People's Hospital
3. Dept of Traditional Chinese, Tibetan Medicine Research Centre, Medical College, Qinghai University
Publication Type:Journal Article
Keywords: diabetes mellitus; oxidative stress; pancreatic tissue; PI3K/AKT/Nrf2 signaling pathway; proanthocyanidins; rubus amabilis focke
From: Chinese Pharmacological Bulletin 2021;37(9):1219-1224
CountryChina
Language:Chinese
Abstract: Aim To study the protective effect of proanthocyanidins extracted from Rubus amabilis Focke (RPC) on the pancreatic tissues of diabetic mice and the underlying mechanism. Methods C57BL/6 male mice were given a high-sugar and high-fat diet combined with an intraperitoneal injection of STZ to establish the diabetic model. The mice whose FBG were higher than 16. 7 mmol · L