Research progress on mechanisms of AMPK in diabetes prevention and control
10.3969/j.issn.1001-1978.2021.09.005
- Author:
Ming-Hui CHENG
1
;
Hong QIN
1
Author Information
1. Dept of Nutrition and Food Hygiene, Xiangya School of Public Health, Central South University
- Publication Type:Journal Article
- Keywords:
AMPK;
browning of white adipose;
diabetes;
glucose and lipid metabolism;
inflammation;
oxidative stress
- From:
Chinese Pharmacological Bulletin
2021;37(9):1208-1212
- CountryChina
- Language:Chinese
-
Abstract:
AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a key role in the maintenance and regulation of energy homeostasis in body. It is an important regulator of energy metabolism. Numerous studies have shown that AMPK plays an important role in the prevention and control of diabetes. AMPK can activate or inhibit a variety of downstream effectors, thereby regulating a variety of physiological activities, including regulating glucose and lipid metabolism, promoting browning of white adipose, anti-inflammatory, antioxidant stress, etc. In this review, the mechanisms of AMPK preventing the occurrence and development of diabetes were reviewed, aiming to provide a reference for the development of safe and effective new AMPK targeting drugs.
