Application and prospect of organoid culture in cancer
10.3969/j.issn.1001-1978.2021.09.003
- Author:
Yu-Xin XIE
1
;
Feng-Sheng XU
1
;
Tong WANG
1
;
Chun-Yu YANG
1
;
Xue-Bing ZHOU
1
;
Xiang-Shan REN
2
;
Xiang-Shan REN
3
Author Information
1. College of Medicine, Yanbian University
2. Cancer Research Center of Yanbian University
3. State Key Laboratory of Civil Affairs, Key Laboratory of Science and Technology, Dept of Jilin Province
- Publication Type:Journal Article
- Keywords:
cancer;
new drug development;
organoid;
precise treatment;
research status;
tumorigenesis
- From:
Chinese Pharmacological Bulletin
2021;37(9):1197-1201
- CountryChina
- Language:Chinese
-
Abstract:
At present, the traditional models for cancer research include the 2D cell model, human tumor xenograft model and animal model. With the deepening of research, the traditional tumor model is unable to meet the needs of researchers. Organoid model is derived from the surgical specimens of tumor patients, which can completely preserve the histological and genomic characteristics of tumor. It can be used in the research of tumor pathogenesis, drug screening, personalized treatment of patients, etc. Compared with traditional model, it has the advantages of short modeling time, economic benefits and closer-ness to the characteristics of the original tumor. This paper mainly focuses on the research status of organoid technology in tumor, the application of organoid model in treatment, and the advantages of organoid model compared with traditional model, so as to provide reference for the follow-up research.
