Effect of Bigelovii A on hepatocellular carcinoma by regulating SHP and STAT signaling pathway

Author: Fuqin GUAN ¹ ; Yu SHAN ¹ ; Yu CHEN ¹ ; Qizhi WANG ¹ ; Linwei LI ¹ ; Xu FENG ¹ ; Haiying TONG ² ; Xu FENG ²
Author Information

1. Institute of Botany, Chinese Academy of Sciences, Nanjing Botanical Garden Mem, Jiangsu Key Lab for the Research, Utilization of Plant Resources
2. Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden Mem. Sun Yat-Sen, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm
Publication Type:Journal Article
Keywords: apoptosis; Bigelovii A; HepG2 cells; interleukin-6; SH2-containing protein tyrosine phosphatase; signal transducer and activator of transcription
From: Chinese Pharmacological Bulletin 2021;37(2):192-195
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of Bigelovii A on HepG2 cell apoptosis and its possible mechanism. Methods MTT assay was used to determine the inhibitory effect of Bigelovii A on HepG2 cells. Flow cytometry was performed to detect apoptosis. Western blot was applied to detect the expression of proteins of STAT pathway. Results BA (20 μmol L